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Vindis C, Escargueil-Blanc I, Elbaz M, Marcheix B, Grazide MH, Uchida K et al

At 6 weeks of age, mice were housed in plastic cages and received standard chow (AIN-76) and water ad libitum prior to experiment maintained on a 12 h/12 h light/dark cycle

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Among tyrosine kinase inhibitors, imatinib (a PDGFR inhibitor) and erlotinib (an EGFR inhibitor) induce ROS-dependent apoptosis in melanoma and non-small-cell lung cancer cells, respectively, through disruption of mitochondrial membrane potential upon the stimulation of JNK and p38 phosphorylation 88,89 , while vemurafenib (a BRAF inhibitor) increases the production of superoxide anions with the commensurate depolarization of the mitochondrial membranes in melanoma cells 90

Conclusions In this study, 16S rRNA sequencing, metabolomics, metabolite traceability, and molecular docking techniques were integrated to demonstrate that there was a cross-talk between gastric mucosal microbes and mitochondria