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Retrospective analysis of OA progress in type 2 diabetes patients showed the lower ratio of knee arthroplasty in patients treated with metformin, suggesting the possibility of clinical effectiveness

Chronic exposure to selenium enhances oxidative stress in the brain and leads to cognitive impairment in animal models [194,195]

Loss of ORP5 alters mitochondrial PA levels, leading to increased cardiolipin synthesis and mitochondrial hyperfusion, while ORP5 overexpression promotes TAG synthesis and LD growth

Fe 2+ is released from lysosomes into the cytosol before transport into the matrix across MCFU, an electrogenic Ca 2+ /Fe 2+ uniporter ( Figure 13 )

720 These abnormal proliferation-related signals may also be associated with accelerated tumorigenesis