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Whats more, we develop metabolic vitamin B12 deficiency well before we develop a clinical deficiency, so theres a missed opportunity to prevent dementia and stroke when we have enough B12 to avoid deficiency symptoms, but not enough to keep our homocysteine in check

Increased expression or activity of NADPH oxidase was reported in coronary and peripheral arteries of patients with coronary artery disease [72,73,74]

SCFAs further alleviate cutaneous photoaging by activating G protein-coupled receptors (GPCRs), downregulating pro-inflammatory cytokines (e.g., IL-1, IL-6), and inhibiting MMP-1/MMP-3 expression, thereby reducing collagen degradation (Peterson et al., 2019)

it is abundant in cells and is a crucial metabolite and substrate in numerous metabolic processes

NK cell percentages were lower in the group with high metabolite levels than in the group with low metabolite levels ( P = 0.04)