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Gastrointestinal alterations in autism spectrum disorder: what do we know

For GSD-1b patients poorly respond to regular treatment, somatic gene therapy is becoming an available choice

Although biochemically separated from the GSH system, the Trx system shares NADPH as a common reducing cofactor and serves as an alternative pathway for reducing disulfide bonds, making this system especially relevant if the GSH system has been compromised or rendered dysfunctional (Silva-Adaya et al., 2014)

The primary function of the urea cycle is to process this excess ammonia into urea which can then be eliminated through excretion by the kidney