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For example, instead of 10mg once weekly, a patient might inject 5mg twice weekly

If you are opting for the B12 injection, it will be performed by a highly qualified, licensed professional who is under the supervision of a medical doctor

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ER stress, ROS generation, and ferroptosis are possibly related, but the mechanisms driving lipid peroxidation in the ER and its relationship to ferroptosis are still unclear

In addition, novel regulators such as RNA methylation enzymes (METTL3/14) that modulate GPX4 mRNA stability (176), or RhoA-mediated vascular remodeling that enhances iron leakage into subchondral bone ( Future research should leverage high-resolution single-cell or spatial omics, functional validation in cell-specific knockout models, and joint-region-targeted delivery systems to develop more personalized and mechanistically guided ferroptosis interventions