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This transient, noise-induced paradoxical phenomenon, which precedes the eventual silencing of auditory nerve fibers and synapses, may be characterized by (1) excessive glutamate release from IHCs, resulting in overactivation of receptors on auditory nerve fibers 66 , and (2) functional compensation by LOC efferent neurons, ensuring that auditory nerve activity is enhanced during periods of increased demand 67 , consistent with evidence suggesting that a primary function of LOC efferents is to reduce auditory neuropathy 68

IGF-1 LR3 (Long R3 IGF-1) is the active mediator of growth-hormone signaling, modified for stability

According to this classification system, gliomas can be divided into adult diffuse gliomas, diffuse low-grade gliomas in children, diffuse high-grade gliomas in children and localized astrocyte gliomas

doi: 10.1016/j.fbio.2022.101807 135 SengulEYildirimSCinarTekinSDagYBolatMet al

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