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Single-cell RNA sequencing reveals heterogeneity and functional diversity of lymphatic endothelial cells

Med 8 , 885889 (2002)

Notably, H3K18la enhances SOX9 transcription, a key fibrosis factor, indicating that this pathway may present novel therapeutic opportunities for hepatic fibrosis treatment (90)

Furthermore, pharmacokinetic investigations are necessary to ascertain remogliflozin levels in hepatic tissue and to examine whether direct hepatic mechanisms or systemic metabolic enhancements facilitate its hepatoprotective effects

10.1038/sj.bjc.6605954 208 WatanabeT.MitsuhashiM.SagawaM.RiM.SuzukiK.AbeM.et al (2013)