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Repeated and frequent episodes of hyperammonaemia (alongside metabolic decompensations) can result in impaired growth and intellectual disability, the severity of which increase with longer duration of hyperammonaemia

This compound demonstrates remarkably potent genotoxic effects in colonic epithelial cells, operating through mechanisms distinct from classic NOCs: it generates reactive oxygen species, lipid peroxidation products, and DNA-reactive aldehydes at concentrations five- to sixfold lower than required for equitoxic effects from non-nitrosylated heme (16)

Brain Res 1701:153160 Tauris J, Christensen EI, Nykjaer A, Jacobsen C, Petersen CM, Ovesen T (2009) Cubilin and megalin co-localize in the neonatal inner ear

Therefore, we used a hybrid approach in this study to compensate for the shortcomings of each method (Yugi et al., 2005)

Moroni I, Bugiani M, DIncerti L, Maccagnano C, Rimoldi M, Bissola L, et al