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J Cell Biol 138:13791394 Chen C, Krausz KW, Idle JR, Gonzalez FJ (2008) Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

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The peptide binds to GHRH receptors on somatotroph cells in the anterior pituitary, triggering a cascade that increases intracellular calcium and activates protein kinase C, which then causes vesicular fusion and GH secretion into circulation