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Expression of angiogenesis-related molecules in plexiform lesions in severe pulmonary hypertension: evidence for a process of disordered angiogenesis

HoFH in Adult and Pediatric Patients In an open-label, forced-titration study, HoFH patients (n=40, 8-63 years) were evaluated for their response to rosuvastatin 20 to 40 mg titrated at a 6-week interval

Upon activation, these caspases cleave gasdermin D (GSDMD), which then binds to lipids at the plasma membrane and forms oligomeric pores, thereby leading to pyroptosis

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However, the described impairments of Tg4-42 mice cannot be attributed to an increased thigmotaxis as transgenic mice did not differ from WT animals in thigmotaxic swims, floating rate, or swimming speed