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These data revealed that Cagri generally had a similar binding mode to amylin peptides but distinct receptor complex dynamics at the calcitonin-family receptors compared to other peptides

Recent studies of peptide-bound, active, Gs-coupled, structures of CTR or AMYRs provide evidence supporting distinct conformations of receptors when bound to CT peptides versus amylin peptides 15 that may contribute to pharmacological differences between dual CTR and AMYR agonists

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