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Specific TP53 subtype as biomarker for immune checkpoint inhibitors in lung adenocarcinoma

Patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use tirzepatide

In the Krebs cycle, adenosylcobalamin can induce the accumulation of succinate, an antagonist of histone and DNA demethylation reactions catalyzed by enzymes of the 2-oxoglutarate-dependent dioxygenase family, which may favor the activation or inhibition of gene expression ( Figure 5 )