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And in my sickest patients, I would have to drive the blood level that high

Diabetic polyneuropathy in type 2 diabetes mellitus: inflammation, oxidative stress, and mitochondrial function

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and transformation of muscle fibers from type I (slow twitch) to type II (fast twitch), particularly type IIB, which possess less oxidative capacity than type IIA or type I fibers

Mitochondria are the main source of ROS, generated from the ETC/OXPHOS and any excess release of toxic free radicals could trigger OxS and m -Dys 589