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Note that in the majority of the participants, the weight loss obtained is well above 5% of the initial weight (the minimum associated with an improvement in health) and even exceeds 20% in many of them, in particular in the participants who received tirzepatide

When comparing V2 with V0, 77 proteins were upregulated, whereof 58 (75%) were classified as leakage proteins and 39 upregulated were linked with various GO-BP terms, including blood coagulation, fibrin clot formation, protein maturation, positive regulation of cell-substrate adhesion, metal ion responses, positive regulation of substrate adhesion-dependent cell spreading, and cell adhesion (Fig

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