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Notably, in most countries PAC is freely sold as an OTC drug, raising the risk of unintentional abuse and increased adverse effects ( No answer can be given to the above open questions because PAC efficacy/adverse effects, unlike most of the drugs repositioned for COVID-19 therapy, have not yet been evaluated in controlled clinical trials or analyzed through retrospective analyses

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CPPs have been used in animal cells to deliver genome-editing elements as RNPs non-biolistically, and these short, positively charged peptides were shown to translocate across cell membranes with high delivery efficiencies (Liu et al., 2014