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The benzyl alcohol does not kill bacteria outright, but it blocks them from multiplying, which is exactly what a multi-dose vial needs

Embodiment A69 (a further embodiment of Embodiment A1) provides a compound that is (2R)-2-(5-Fluoro-2-methoxypyridin-4-yl)-1-[(2S)-7-methyl-6-(pyrimidin-2-yl)-3,4-dihydro-1H-spiro[1,8-naphthyridine-2,3-pyrrolidin]-1-yl]propan-1-one

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However, NAC treatment did not provide survival benefits at the 6-month mark for patients with severe AH compared with a placebo (NCT00962442) [250]