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Huber KM, Kayser MS, Bear MF (2000)

This could occur e.g

These distinct evolutionary classes include Alpha, Beta, Dehydroascorbate reductases (DHARs), Delta, Epsilon, Mu, Omega, Pi, Phi, Sigma, Tau, Theta, and Zeta

Regardless of the genetic contribution to disease, TRAP1 at least appears to play an important regulatory role in mitochondria that is relevant for the fine tuning of energy metabolism