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Blockade of IL-17 signaling pathway effectively reverses alcohol-associated hepatic injury and compulsive drinking behaviors in dependent mice [140, 235], suggesting therapeutic potential of inflammatory cytokine targeting along the brain-liver axis

This may induce a generalised vessel failure, stasis, and thrombosis peripherally and centrally as well as heart failure

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Thanks to an isogeneic approach and the unique potential of hybrid configurations, they constitute an invaluable tool to study how the crosstalk within an organ microenvironment determines disease phenotype