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Further research has revealed that brain areas with iron accumulation exhibit mitochondrial swelling and neuronal apoptosis (Zhao et al., 2016)

Specifically, the ApoE4 allele is a significant risk factor for SAD, while ApoE2 allele provides protection compared to the more common ApoE3 allele

doi: 10.1016/j.neulet.2018.06.023

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There was no significant difference observed for in-hospital mortality, hospital-free days, total health-care costs, and sepsis development between those who received an elemental diet (Elental, n = 382) and those who received non-elemental enteral nutrition (n = 566) [35]