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prescription drugs by sales are largely expensive, specialized therapies (often biologics) for serious chronic illnesses (cancer, diabetes/obesity, autoimmune disease, etc.)

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Genetically lowered concentrations of circulating sRAGE might cause an increased risk of cancer: Meta-analysis using mendelian randomization

This finding was supported by reports of two selective serotonin reuptake inhibitors (SSRIs) developed to treat depression, fluoxetine and sertraline, being associated with non-sustained weight loss in obese subjects

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