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5-Amino-1MQ is a small-molecule NNMT inhibitor

By inhibiting NNMT, 5-Amino-1MQ effectively disrupts this process, leading to a reduction in fat storage and promoting increased fat oxidation

37 However, peptides derived from mammalian tissues and synthetic sources often encounter pharmacokinetic limitations, including rapid degradation, short plasma half-life, and poor oral bioavailability