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In global cerebral ischemia, the central part of the ischemic region does not receive any blood supply, but a small amount of blood can still reach this area through collateral circulation

Intracellular fluid (cytosol) has up to 10 mM of GSH whereas the plasma GSH concentration is very low (micromolar range) (Figures 1, 2)

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FIGURE 1 3.2 Formononetin inhibits breast cancer proliferation in vivo In order to validate the in vivo anti-tumor efficacy of Formononetin, nude mice were subcutaneously injected with MDA-MB-231 cells to establish a mouse xenograft tumor model