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In fact, the overexpression of mitochondrial GPx4, but not nonmitochondrial GPx4, suppressed mitochondrial oxidative stress (36) and apoptosis mediated by the mitochondrial pathway in rat basophile leukemia cells (RBL2H3 cells) (37), suggesting that nonmitochondrial GPx4 plays a limited role in mitochondria (38)

Notably, ER-4 exhibits high metabolic activity compared to the other ER+ patients

Notably, methylation levels of intragenic CpG islands are higher than those of promoter CpGs during embryonic development, suggesting their potential role in tissue-specific reprogramming [57]

Near-infrared light therapy has been shown to improve cognitive function and activities of daily living in AD patients (Chen et al., 2023)

To date, NACA has been shown to have antioxidant activity in several preclinical models, but is yet to be approved for clinical use