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J Cell Mol Med 18:15991611 Guo Q, Guo JB, Yang R, Peng H, Zhao J, Li L et al (2015) Cyclovirobuxine D attenuates doxorubicin-induced cardiomyopathy by suppression of oxidative damage and mitochondrial biogenesis impairment

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Introduction Mitochondria play crucial roles in different aspects of cellular physiology, including calcium homeostasis, metabolism, apoptosis and ATP production (Rizzuto et al., c oxidase (COX)), while the gradient of protons is necessary for the ATP synthesis via complex V (ATP synthase

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