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An inhibitor of oxidative phosphorylation exploits cancer vulnerability

Koren S A, Ahmed Selim N, De La Rosa L, et al

The procedure began with manual selection of the initial pose to ensure proper orientation of both molecules for membrane embedding and to position some of the surface-exposed cysteines of CYP2E1 (C261, C268, C480, and C488) in proximity to the TFMD-tagged regions of CYP3A4