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In vitro studies using MDCK cells (a model of intestinal epithelial permeability) demonstrated that PLGA nanoparticles significantly enhanced cellular uptake and transport of puerarin across cell monolayers, achieving a permeability coefficient value of 2.83 0.27 10 5 cm/s, which was significantly higher than that observed for free puerarin (0.38 0.07 10 5 cm/s)

You must use trial and error, starting with a standard initial dose and gradually increasing the amount until you obtain the best results

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5 In this article, we will combine the most up-to-date and clinically relevant efficacy data, the most recent cost data and the latest epidemiology data from a large Italian ICU database to determine whether i.v