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These enzymes dephosphorylate TCR signaling molecules, which in turn inhibit classical antigen-specific T cell receptor (TCR) function and downstream signaling via the PI3K-AKT and mTOR pathways

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For those with a temporary deficiency or improved dietary intake, our providers may recommend switching to oral supplements or eventually discontinuing injections altogetheralways under careful medical supervision

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Proc Natl Acad Sci USA 98: 247252 [DOI] [PMC free article] [PubMed] [Google Scholar] Yeh C.Y., Shin S.M., Yeh H.H., Wu T.J., Shin J.W., Chang T.Y., et al