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The mechanisms involved in physiological cellular senescence make RGCs and their axons more vulnerable to glaucoma-associated changes leading to more rapid cell loss

Notably, MYC, a key transcription factor implicated in the cellular response to DILI and liver pathology, was among these targets 20,21

O2- can release iron ions under stress conditions from the iron-sulfur of proteins, participating in the Fenton reaction and converting H2O2 to OH (40)

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