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Inhibitors of FASN (such as TVB-2640, which has advanced to clinical trials) and acetyl-CoA carboxylase (ACC) inhibitors have shown preclinical efficacy in reducing tumor growth and overcoming resistance to targeted therapies

Along with its angiogenic and cytoprotective enzyme functions, HO-1 performed crucial biological activities, making it highly significant in the wound healing process

The oxidative stress gene polymorphisms may affect the disease, independently of the type, although there is a high data variability due to the difference in genotype frequency among ethnicities and the possibility of functional compensation by other genes