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Studies have demonstrated that astaxanthin treatment can alleviate mitochondrial dysfunction and rescue kidney function via its antioxidant activities in several kidney diseases, such as DKD (Naito et al., 2021) and bisphenol A-induced kidney toxicity (Jiang et al., 2020b)

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Therefore, we hypothesized that a combination of supplements (one targeting nitric oxide bioavailability (AAL-anti-atherosclerotic liquid), one targeting systemic inflammation (AIC- anti-inflammatory capsules), and one providing broad antioxidant support (AOL- antioxidant liquid)) would yield a more comprehensive and synergistic benefit than any single agent alone