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10.1371/journal.pone.0219531 127 NewtonJ

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The mechanisms through which progestins exert their therapeutic effects are the anti-estrogenic effects, anti-vasculogenic action, induction of apoptotic cascade in endometriotic cells, suppression of inflammatory pathways (as production of metalloproteinases), cell proliferation suppression, and also anti-neurogenic effects with inhibition of nerve growth within endometriotic lesions [59, 63, 64]

Though there is not conclusive evidence comparing the extent of functional benefits provided by the 2 therapies, based on the data presented within the MAIC analysis of the drugs clinical trials, one can hypothesize that pegcetacoplan may have a greater effect than avacincaptad pegol on preserving visual function, and patients may be able to protect their driving and reading abilities for a longer period of time