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Description

[151] [152] [153] TAAR1 activation by methamphetamine in astrocytes appears to negatively modulate the membrane expression and function of EAAT2, a type of glutamate transporter

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( Tnf, Il6, Il1b ) and downregulates pro-fibrotic genes ( Acta2, Col1a2, Tgfb1, Pdgfrb, Pdgf-b, Pdgf-c ), reducing -smooth muscle actin (-SMA) and platelet-derived growth factor receptor beta (PDGFR) protein levels (73)