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Structure superimposition demonstrated that the epitope for WRAIR-5001 is occluded by the adjacent S protomers when the RBD is in the down conformation while more accessible when RBD is in the open conformation, indicating the cryptic nature of this epitope in line with other mAbs in class III or class V

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The different expression levels observed in APP/PS1 animals, especially for the m- Gpx4 isoform, suggest a genotype-related transcriptional regulation, which fits well with the increased levels of hippocampal oxidative stress demonstrated in transgenic animals (Aso et al., Table 1 Oligonucleotides used as primers for quantification of different Gpx4 mRNA isoforms and for mapping 5 end of I - Gpx4 mRNA in HT22 cells and mouse hippocampus

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