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However, RNAi therapeutics still face technical obstacles, such as achieving efficient delivery of RNAi drugs targeting organs or tissues and overcoming the off-target interactions (Doench et al., 2003

Supportive secondary endpoint analyses were not controlled for multiple comparisons and should not be used to infer definitive treatment effects

Research models with obesity, insulin resistance, or age-related metabolic decline typically show both AMPK suppression (which MOTS-c corrects) and NNMT overexpression (which 5-Amino-1MQ corrects)

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