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Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion

The nutrient deficiency can also activate the NOD-like receptor (NLR) family and pyrin domain-containing 3 (NLRP3) inflammasome and induce IL-1 secretion in high fat diet-induced atherosclerosis animal model 48 , whereas zinc supplementation can inhibit NLRP3 inflammasome activation through its antioxidant effects in an in vitro study 49

In this regard, increasing public awareness, in particular among farmers and local food/feed producers, plays a critical role in elimination of AFs and preparing countries local society to deal with complications of GCC and health threatening environmental risk factors

PLC 2 Phosphatidylinositol-specific phospholipase C gamma 2 (PLC2) has emerged as a significant regulatory enzyme in cellular signaling, primarily through its catalytic role in breaking down membrane-bound phospholipids to produce diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) [157]