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Clinically, patients with irritable bowel syndrome (IBS) exhibit altered gut microbiota composition, such as increased Pseudomonadota (basonym Proteobacteria) and decreased bifidobacteria, which correlates with abnormal overexpression of 5-HT3 receptors in colonic tissue

Annual monitoring (CBC, electrolytes, LFTs, renal and thyroid function) is advised if saffron is used adjunctively

Interestingly, we also noticed that three hydrophobic amino acids are also present in other of the most aggressive HPV strains (18, 31, 33, 45 and 59) at positions corresponding to the residues Val 55, Phe 57 and Met 84 of HPV-16 E7, while the hydrophobic character of the same amino acid sites is poorly conserved across all HPV strains

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