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The approval of istradefylline paves the way for novel therapeutic opportunities of A2A antagonists, while underlining the need for identification of patient subgroups that would benefit from these agents

However, direct cartilage injection of IGF-1 more effective than systemic elevation, and systemic growth hormone peptides produce modest IGF-1 increases (not pharmacological levels)

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Funding The present study is fully supported by the Division of Intramural Research of the National Institute of Nursing Research of the National Institutes of Health, Bethesda, MD, United States (grant number: ZIA NR000020-06)

I had similar but not as excessive as your experience