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Collectively, these studies demonstrate that by targeting mitochondrial integrity and normal mitochondrial function in peripheral neurons, it represents a new therapeutic strategy for treating CIPN

The anti-inflammatory activity of paeoniflorin and its derivatives, 4-O-methylbenzoyl paeoniflorin, 4-O-methyl paeoniflorin, and other monoterpenes was reported ( 5 Antioxidants: Mode of action and molecular mechanisms The mode of action of antioxidants can be explained by the following routes

Our work demonstrates that 4-HNE is a previously unappreciated component of ROS-mediated toxicity and that L

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Consequently, changes in the ROS levels inside the cancer cells in a 1% O 2 atmosphere were examined by utilizing the ROS specific probe 2,7-dichlorodihydrofluorescein diacetate (DCFH-DA) which is chemically converted into a green fluorescent dye in the action of ROS