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Rahbar, A

Results GSH depletion induces cell death in RPE cells To evaluate the effect of GSH depletion on the RPE cells, we used three different approaches: depletion of Cys 2 from cell culture media, treatment with buthionine sulphoximine (BSO, 1000 M) to block de novo synthesis of GSH, or treatment with erastin (10 M), an inhibitor of system x c 1

2 Energy metabolism in neurons 2.1 Core characteristics and substrate preference of neuronal metabolism Neurons, in comparison to glial cells, maintain a higher energy level due to their continuous need to generate action potentials, synaptic potentials, and neurotransmitters

79 In fact, an analysis of the iPSC and stem cell transcriptomes showed highly upregulated levels of NAMPT

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