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2.6.3 Association mechanism between NADPH metabolic imbalance and ferroptosis Nicotinamide adenine dinucleotide phosphate (NADPH), is closely associated with the pathogenesis and progression of various metabolic diseases, and plays a pivotal role in ferroptosis regulation by modulating antioxidant system function and iron metabolism homeostasis, with its intracellular levels directly dictating cellular susceptibility to ferroptosis (145, 146)

Conclusions Immunothrombosis is an important pathological feature of inflammatory conditions and infections like COVID-19

In the case of CAD, instead of nitric oxide, superoxides occur, leading to oxidative stress, which damages the vasculature and leads to atherosclerotic plaques and chronic inflammation [63]

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17 It has been revealed that the inflammation has an important role in the pathogenesis of CS, and various inflammatory markers have been investigated as predictors of the disease