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Interestingly, investigations on females with diminished ovarian reserve have shown that the supplementation with IGF increases LHR, FSHR, and GHR expression in isolated human granulosa cells

Antioxid Redox Signal 15: 29112921

Obesity-dependent increases in oocyte mRNAs are associated with increases in proinflammatory signaling and gut microbial abundance of lachnospiraceae in female mice

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For instance, under conditions of environmental heat stress, supplementation with L-citrulline was shown to significantly improve hemodynamic parameters in camel testicular tissue, as evidenced by increased testicular blood flow, tissue volume, and elevated NO levels ( Figure 3d )