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PMID: 35083444

10.1136/bmj-2024-080952 91 SunZ.ZhaoH.FangD.DavisC

doi: 10.1016/j.cmet.2006.02.004

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and (ii) delivery-related issues, as PLGA nanoparticles require further engineering to achieve high selectivity and specificity, overcome BBB restrictions, and effectively target pathological sites, and/or multi-targeting strategies may be necessary as AD exhibits multiple pathological targets (Lu et al., 2023)