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Dissociated hippocampal neurons transfected with mRFP- -actin were stimulated for 5 days with sub-threshold concentrations of HGF and Dihexa (2.5 ng/ml+10 13 M, respectively), biologically active doses of HGF (10 ng/ml), Dihexa or Nle1-AngIV (10 12 M) or a combination of sub-threshold doses of 2.5 ng/ml HGF+10 12 M Dihexa or 2.5 ng/ml HGF+10 12 M Nle1-AngIV

Research Highlights Co-administration shows markedly greater bodyweight reduction than either monotherapy 1

310 min, linear decrease in A from 15 to 0%

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This enhanced the permeability and efficacy in treating neurological diseases, including PD (130)