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When the daily dose of acetaminophen exceeds 4 grams, the sulfated conjugation pathways become saturated, which diverts acetaminophen metabolism to the pathway with the toxic metabolite

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If the 4 mg maintenance arm proves non-inferior for weight maintenance in Phase 3, researchers may be able to titrate up to a high working dose during the active weight-loss phase, then step back down to a lower 4 mg maintenance dose for the long stabilization phase