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Am J Physiol Ren Physiol 307(6):F660F665 Marini JC, Agarwal U, Didelija IC (2015) Dietary arginine requirements for growth are dependent on the rate of citrulline production in mice

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Autophagy can regulate the proliferation and size of pancreatic -cells, reduce insulin resistance, prevent diabetic nephropathy, and limit progression of DM through promoting -cell function and eliminating misfolded proteins and dysfunctional mitochondria

Furthermore, intestinal infections are an important factor in the development of IBD (51) and most of the evidence available to date supports the notion that HMOX1 promotes bacterial clearance, diminishing intestinal inflammation (90)

In the early adhesion phase, immune defenses are active: neutrophils and M1 macrophages target bacteria via phagocytosis, oxidative bursts, increased antimicrobial peptides (AMPs), reactive oxygen species (ROS), and pro-inflammatory cytokines (IL-1, IL-6, TNF-) and chemokines