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Nicotinamide N-methyltransferase (NNMT) is a cytosolic enzyme that catalyzes the methylation of nicotinamide using S-adenosylmethionine (SAM) as a methyl donor, producing 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine (SAH)

Doses of vitamin B 12 exceeding 10 mcg daily may produce hematologic response in patients with folate deficiency

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In a randomized trial published in Metabolic Brain Disease, adults with generalized anxiety disorder who took vitamin D for three months showed significant anxiety improvement and elevated serotonin levels

This is an entirely separate regulatory path from drug approval and does not imply it is safe or effective as a therapeutic agent