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We hypothesize that the excess GSSG in cytosol were transported to extracellular space where class III peroxidases locate and served as the oxidant either directly or indirectly during ROS production by class III peroxidases (Figure 6)

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Mete O, Asa SL, Baloch ZW, Erickson L, Ezzat S, Rotstein L, Sawka AM, Seethala RR, Zafereo ME

Several viral infections, and the progression of virus-induced diseases, especially those associated with COVID-19, are characterized by an alteration in the intracellular redox balance (Polonikov, 2020)