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CRISPR/Cas9-mediated knockout of autophagy regulators ATG5/ATG7 in RPMI-8226 MM cells significantly increased cell viability compared to wild-type controls upon RSL3-induced ferroptosis, confirming autophagys synergistic role in ferroptotic execution ( 6.5 Other regulatory mechanisms The interplay between ferroptosis and epigenetic regulation has garnered increasing attention due to their shared associations with oxidative stress and dysregulated iron metabolism

A thiohydroximate-O-sulfonate group (-S-(C = N)-OSO) linked to the C1 position of glucose, and

Pradel B, Robert-Hebmann V, Espert L

BSPs pretreatment can inhibit the increase of Keap1 protein induced by p31-43, activate antioxidant genes through Nrf2 protein, improve the activity of the antioxidant enzyme, alleviates glutathione redox cycle imbalance, promote the expression of GCLC or GCLM, and reduce oxidative damage

Andrology 2019