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The melanoma-associated cancer-testis (CT) antigen (MAGE) is reactivated due to DNA hypomethylation in melanoma and colorectal cancer, which promotes the development of melanoma and colorectal cancer (Kim et al., 2006)

[31] Echeverria D, Aposhian HV, Woods JS, Heyer NJ, Aposhian MM, Bittner AC, Mahurin RK, Cianciola M

doi: 10.3389/fimmu.2020.545413 Received 24 March 2020 Accepted 22 October 2020 Published 19 November 2020 Volume 11 - 2020 Edited by Mary Jane Thomassen, East Carolina University, United States Reviewed by Juerg Hamacher, Lindenhofspital, Switzerland

Alliance 6 , e202302116 (2023)

For example, metformin is well-known for its diverse effects, including recently reported anti-inflammatory activity