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After incubation with hypo-osmotic swelling solution [HOS, containing 6.75 g/L fructose and 3.67 g/L sodium citrate] at 37C for 1 h, plasma membrane integrity of each group (repeated in triplicated)was analyzed by evaluating the modifications of sperm tail to score swollen sperm according to previous publications (27, 61)

All these patients had defects in DMEs genes and also harbored T315I kinase domain mutation already associated with nilotinib non-responsiveness in CML patients [6]

Rapamycin and the recently developed more specific mTOR inhibitors, i.e., rapalogs, are promising therapeutic compounds in the treatment of cancers and several autoimmune and chronic inflammatory diseases [66]

In addition, in vitro assay demonstrated that full-spectrum hemp oil exerts pronounced antioxidant, antifungal, and anticancer effects over a concentration range of 15300 g/mL following a single 72 h exposure [227]

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